Research sheds light on what shapes human gut microbiome

CHICAGO, Oct. 9 (Xinhua) -- A study posted on the website of Northwestern University (NU) on Tuesday finds that despite human's close genetic relationship to apes, the human gut microbiome is more similar to that of Old World monkeys like baboons than to that of apes like chimpanzees.

The results suggest that human ecology has had a stronger impact in shaping the human gut microbiome than genetic relationships. The results also suggest human gut microbiome may have unique characteristics compared to other primates, including increased flexibility.

Host ecology is what drives gut microbiome composition and function, and chimpanzees have very different habitats, diets and physiologies than humans, said Katherine Amato, lead author of the study and assistant professor of anthropology in the Weinberg College of Arts and Sciences at NU.

"We need to look to primates with similar ecology and physiology as humans to understand the human gut microbiome," she said. "Old World monkeys like baboons appear to be the best starting point for this."

According to Amato, if ecology is really the most important driver of primate gut microbiomes, the human gut microbiome should be distinct from that of other apes. Moreover, it should be more similar to other primates that use similar environments and diets as human ancestors did and have more similar associated physiological adaptations.

"Chimpanzees are often assumed to be the best models for humans in many aspects of science due to their high relatedness to us," she said. "Our results show that this assumption is incorrect for the gut microbiome."

The researchers need to think about the human gut microbiome and its evolution differently, Amato added.

In the next step, the researchers plan to explore in more detail which human gut microbial functions are shared with Old World monkeys and what impact they have on human biology and physiology.

"Pinpointing these relationships will provide further insight into the services gut microbes may have provided humans across evolution," Amato said.

[ Editor: SRQ ]
 

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