Chinese scientists develop new treatment for tendon-bone injuries

This diagram provided by the Shanghai Institute of Ceramics (SIC) of the Chinese Academy of Sciences, shows how an immunomodulatory multicellular scaffold based on manganese silicate (MS) nanoparticles is used for integrated tendon-to-bone regeneration. (Xinhua)

SHANGHAI, March 18 (Xinhua) -- A Chinese research team has developed a multicellular scaffold based on inorganic bioceramics for treating tendon-to-bone injuries.

Restriction of motor activity due to loss of natural structure is a major cause of decreased life quality in patients suffering from tendon-to-bone injuries.

To solve this problem, the research team, led by the Shanghai Institute of Ceramics (SIC) of the Chinese Academy of Sciences, combined manganese silicate (MS) nanoparticles with tendon/bone-related cells to construct an immunomodulatory multicellular scaffold to achieve integrated tendon-to-bone regeneration.

The scaffold not only demonstrated diverse biological activities in vitro, but also achieved immune regulation, multi-tissue integration regeneration and motor function recovery in a variety of animal models of rotator cuff injury.

The study provides a new concept for achieving immunomodulation and integrated regeneration of tendon-bone and other tissue interfaces, said Wu Chengtie with the SIC, who led the research.

The study was recently published in the journal Science Advances.